The 4th arrondissement of Lyon (French: 4^e arrondissement de Lyon) is one of the nine arrondissements of the City of Lyon.

The 4th arrondissement of Lyon was created on 24 March 1852 (date of creation of the first five arrondissements), with the same borders of the old town of La Croix-Rousse.

Dominique Bolliet (PS) is currently the mayor of this arrondissement.